TMC CryoEM discussion group public seminar: Structural and Functional Analysis of Transcription Kinases
Fri, Oct 28
|online envent
This is the TMC cryoEM discussion group's public seminar. Presenter: Kuang-Lie Tsai, UTHealth Title: Structural and Functional Analysis of Transcription Kinases
Time & Location
Oct 28, 2022, 12:00 PM – 1:00 PM CDT
online envent
Guests
About the event
Kuang-Lie Tsai, UTHealthPresenter:
Structural and Functional Analysis of Transcription Kinases Title:
Abstract:
The eukaryotic Mediator complex, including a large core and a Cdk8 kinase module, plays an essential role in the regulation of RNA polymerase II (Pol II) transcription. A detailed understanding of Mediator’s structure and interactions is critical for determining how the complex influences transcription initiation and conveys regulatory information to the basal transcription machinery. In addition, Cdk7 is one subunit within the general transcription factor TFIIH that phosphorylated the CTD of Pol II. My talk will focus on the structure and function of two transcription kinases, Cdk8 and Cdk7, and discuss how they are activated through non-canonical mechanisms.
https://med.uth.edu/bmb/faculty/kuang-lei-tsai-phd/Lab page:
Structures and dynamics of macromolecular machines involved in regulation of gene expression; RNA biology; Cryo-electron microscopy and 3D reconstruction techniques; Proteomics.RESEARCH INTERESTS:
Tickets
ticket for seminar 10/28/2022
Your tickets are attached to this email. Don't forget to bring them. We're looking forward to seeing you there. Here are the meeting details: Join from PC, Mac, Linux, iOS or Android: https://bcm.zoom.us/j/96134254526?pwd=Z0Q0V3dvT2d6MTlKQ2VPTXZYU28xdz09 Password: 559357 Or iPhone one-tap: 4086380968,96134254526# Or Telephone: Dial: In Houston: 713-798-9666 +1 346 248 7799 (US Toll) +1 669 900 6833 (US Toll) +1 719 359 4580 (US Toll) +1 253 215 8782 (US Toll)
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